Aging Volume 17, Issue 5

Chronic mild hypoxia (CMH; 8% O2) triggers transient blood-brain barrier (BBB) disruption, an effect greatly increased with age. As BBB disruption predisposes to neuronal death and cognitive decline, here we defined the hypoxic thresholds that trigger BBB breakdown in young and aged mice, and then defined the age at which hypoxia-induced BBB disruption significantly increases.

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Marco Demaria

It is with great enthusiasm and a deep sense of responsibility that I have assumed the role of Editor-in-Chief of Aging-US, effective January 1, 2025. Throughout my career at the intersection of aging research, cellular senescence, and translational science, I have witnessed the transformative potential that deeper insights into the biology of aging can have on healthspan and overall quality of life. This is why I am honored to guide Aging-US into its next chapter.

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