In addition to reducing fracture risk, zoledronic acid has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in animals. Because senescent cells accumulate with aging and contribute to multiple co-morbidities, the non-skeletal actions of zoledronic acid could be due to senolytic (killing of senescent cells) or senomorphic (inhibition of the secretion of the senescence-associated secretory phenotype [SASP]) actions.
Aging (Aging-US) Authors
PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 9, entitled, “In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers.”
PRESS RELEASE: A new editorial paper was published in Aging’s Volume 15, Issue 8, entitled, “The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation.”
PRESS RELEASE: A new review paper was published in Aging’s Volume 15, Issue 8, entitled, “How can we modulate aging through nutrition and physical exercise? An epigenetic approach.”
PRESS RELEASE: A new research paper was published in Aging’s Volume 15, Issue 8, entitled, “Single-cell transcriptomic analysis uncovers diverse and dynamic senescent cell populations.”
Geoffrey Leung and Dr. Doris Leung, Senior Application Scientists from Insilico Medicine Hong Kong Ltd., detail a research paper they co-authored that was published by Aging (Aging-US) in Volume 15, Issue 8, entitled, “Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics – an AI-enabled biological target discovery platform.”
![Figure 1. Overall workflow of the study. [Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform]](https://aging-us.net/wp-content/uploads/2023/05/Screen-Shot-2023-05-02-at-9.40.39-AM-800x600.png)
PRESS RELEASE: A new research paper was published in Aging’s Volume 15, Issue 8, entitled, “Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics – an AI-enabled biological target discovery platform.”
PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 8, entitled, “A chronic wound model to investigate skin cellular senescence.”