The loss of skeletal muscle strength mid-life in females is associated with the decline of estrogen. Here, the researchers questioned how estrogen deficiency might impact the overall skeletal muscle phosphoproteome after contraction, as force production induces phosphorylation of several muscle proteins.

Cell senescence has recently emerged as a potentially relevant pathogenic mechanism in fibrosing interstitial lung diseases (f-ILDs), particularly in idiopathic pulmonary fibrosis. The researchers hypothesized that senescent human fibroblasts may suffice to trigger a progressive fibrogenic reaction in the lung…

To screen for molecules that reverse cellular aging and rejuvenate human cells without altering the genome, researchers developed high-throughput cell-based assays that distinguish young from old and senescent cells, including transcription-based aging clocks and a real-time nucleocytoplasmic compartmentalization (NCC) assay…