This study shows that Elastic Net (EN) DNA methylation (DNAme) clocks have low accuracy of predictions for individuals of the same age and a low resolution between healthy and disease cohorts; caveats inherent in applying linear model to non-linear processes.

Dectin-1 is an innate immune receptor that recognizes and binds β-1, 3/1, 6 glucans on fungi. The researchers evaluated Dectin-1 function in myeloid cells in a cohort of HIV-positive and HIV-negative young and older adults.

The loss of skeletal muscle strength mid-life in females is associated with the decline of estrogen. Here, the researchers questioned how estrogen deficiency might impact the overall skeletal muscle phosphoproteome after contraction, as force production induces phosphorylation of several muscle proteins.