In this cohort study involving 1,676 healthy participants (mean age 40) with up to 15 years of follow up, researchers evaluated the associations between cognitive function and two classes of novel biological aging markers: blood-based epigenetic aging and neuroimaging-based brain aging.
Aging (Aging-US) Authors
Here, the authors screened compounds that could ameliorate senescence and identified an oxazoloquinoline analog (KB1541) designed to inhibit IL-33 signaling pathway.
Researchers repurposed CRISPR/Cas9 epigenetic editing technology in hopes of characterizing transcriptional changes and effects in different tumor settings.
Researchers discovered an enzyme, originally known to regulate the TGF-β, has a previously unreported role in HIF-1α regulation.
In a trending paper published by Oncotarget, researchers developed a divergent strategy to treat non-small cell lung cancer (NSCLC).