Observational studies in preclinical models demonstrate age-related declines in circadian functions. The researchers hypothesized that age would be associated with declines in function of cell-autonomous circadian clocks in human tissue.

In the current study, researchers investigated the neural mechanisms serving working memory (WM) function in seventy-eight healthy aging adults (range: 20.2–65.2 years) using magnetoencephalography (MEG) and a Sternberg WM task with letter stimuli.

SARS-CoV-2 variants are constantly emerging with a variety of changes in the conformation of the spike protein, resulting in alterations of virus entry mechanisms. Solely omicron variants use the endosomal clathrin-mediated entry. Here, researchers investigate the influence of defined altered spike formations to study their impact on premature cellular senescence.

The disturbance of intercellular communication is one of the hallmarks of aging. The goal of this study is to clarify the impact of chronological aging on extracellular vesicles (EVs), a key mode of communication in mammalian tissues.