Observational studies in preclinical models demonstrate age-related declines in circadian functions. The researchers hypothesized that age would be associated with declines in function of cell-autonomous circadian clocks in human tissue.

In the current study, researchers investigated the neural mechanisms serving working memory (WM) function in seventy-eight healthy aging adults (range: 20.2–65.2 years) using magnetoencephalography (MEG) and a Sternberg WM task with letter stimuli.

SARS-CoV-2 variants are constantly emerging with a variety of changes in the conformation of the spike protein, resulting in alterations of virus entry mechanisms. Solely omicron variants use the endosomal clathrin-mediated entry. Here, researchers investigate the influence of defined altered spike formations to study their impact on premature cellular senescence.