“It has long been debated to what extent the mechanisms of aging and progeria overlap.”
BUFFALO, NY- November 9, 2022 – A new research perspective was published in Aging (listed as “Aging (Albany NY)” by MEDLINE/PubMed and “Aging-US” by Web of Science) Volume 14, Issue 20, entitled, “Lamin A to Z in normal aging.”
Almost since the discovery that mutations in the LMNA gene, encoding the nuclear structure components lamin A and C, lead to Hutchinson-Gilford progeria syndrome (HGPS), people have speculated that lamins may have a role in normal aging.
The most common HPGS mutation creates a splice variant of lamin A, progerin, which promotes accelerated aging pathology. While some evidence exists that progerin accumulates with normal aging, an increasing body of work indicates that prelamin A, a precursor of lamin A prior to C-terminal proteolytic processing, accumulates with age and may be a driver of normal aging. Prelamin A shares properties with progerin and is also linked to a rare progeroid disease, restrictive dermopathy.
“Patients with the laminopathy, restrictive dermopathy (RD), have mutations in either ZMPSTE24 or LMNA, the latter associated with altered processing and the accumulation of prelamin A [4, 29]. RD has some phenotypes of accelerated aging; however, the condition is often very early onset and severe, making comparison with normal aging more challenging.”
In this new research perspective, researchers Stanley R. Primmer, Chen-Yu Liao, Oona M.P. Kummert, and Brian K. Kennedy from the Buck Institute for Research on Aging, National University of Singapore and National University Health System describe mechanisms underlying changes in prelamin A with aging and lay out the case that this unprocessed protein impacts normative aging.
“This is important since intervention strategies can be developed to modify this pathway as a means to extend healthspan and lifespan.”
Corresponding Author: Brian K. Kennedy – Corresponding Email: [email protected]
Keywords: lamin A, prelamin A, zmpste24, mTOR, aging
Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204342
AGING (AGING-US) VIDEOS: YouTube | LabTube | Aging-US.com
Launched in 2009, Aging (Aging-US) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
Please visit our website at www.Aging-US.com and connect with us:
- SoundCloud – https://soundcloud.com/Aging-Us
- Facebook – https://www.facebook.com/AgingUS/
- Twitter – https://twitter.com/AgingJrnl
- Instagram – https://www.instagram.com/agingjrnl/
- YouTube – https://www.youtube.com/agingus
- LinkedIn – https://www.linkedin.com/company/aging/
- Reddit – https://www.reddit.com/user/AgingUS
- Pinterest – https://www.pinterest.com/AgingUS/
For media inquiries, please contact [email protected].