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Aging-US.net features press releases on the latest aging research, plus interviews and from the distinguished network of authors who continue to publish their research with Aging-US.

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Aging Journal

Stress granules sequester Alzheimer’s disease-associated gene transcripts and regulate disease-related neuronal proteostasis
Aging News

Stress Granules Control Alzheimer’s Gene Transcripts and Neuronal Proteostasis

June 1, 2023June 1, 2023

PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 10, entitled, “Stress granules sequester Alzheimer’s disease-associated gene transcripts and regulate disease-related neuronal proteostasis.”

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Figure 2. Univariate associations of minor alleles of four SNPs from the MLXIPL gene with AD and CHD in two samples drawn from US cohorts (A) and UK biobank (B).
Aging News

External Factors Shape Genetic Predisposition to Lipids, Alzheimer’s and Heart Disease in MLXIPL Gene

May 24, 2023May 24, 2023

PRESS RELEASE: A new research paper was published in Aging’s Volume 15, Issue 9, entitled, “Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus.”

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Figure 1. Proposed mechanism showing the parallels between age-associated brain and vascular amyloidosis, with both being mediated by sEVs and affected by cellular senescence.
Aging News

Senescence and Extracellular Vesicles: Novel Partners in Vascular Amyloidosis

March 29, 2023March 30, 2023

PRESS RELEASE: A new editorial paper was published in Aging’s Volume 15, Issue 5, entitled, “Senescence and extracellular vesicles: novel partners in vascular amyloidosis.”

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Figure 5. Platelet depletion increases astrocytic coverage of fibrillary amyloid plaques.
Aging News

Aging | Immune-mediated Platelet Depletion Augments Alzheimer’s Disease in Mice

February 15, 2023February 15, 2023

PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 3, entitled, “Immune-mediated platelet depletion augments Alzheimer’s disease neuropathological hallmarks in APP-PS1 mice.”

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Figure 1. A schematic diagram of potential APOE-related mechanism of Alzheimer’s disease (AD).
Aging News

Aging | Associations of APOE ε2 and ε4 Alleles and Polygenic Profiles Comprising APOE-TOMM40-APOC1 Variants With Alzheimer’s Disease Biomarkers

January 3, 2023January 5, 2023

PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 14, Issue 24, entitled, “Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer’s disease biomarkers.”

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Volume 14, Issue 24
Aging Latest Issue

Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer’s disease biomarkers

December 31, 2022December 31, 2022

Capturing the genetic architecture of Alzheimer’s disease (AD) is challenging because of the complex interplay of genetic and non-genetic factors in its etiology. It has been suggested that AD biomarkers may improve the characterization of AD pathology and its genetic architecture…

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Dr. Ya-Jen Chiu
Aging News Spotlight

Behind the Study: Novel TRKB Agonists Activate TRKB and Downstream ERK and AKT Signaling

November 1, 2022November 3, 2022

Dr. Ya-Jen Chiu discusses a research paper she co-authored that was published by Aging (Aging-US) in Volume 14, Issue 18, entitled, “Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity.”

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