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Aging-US.net features press releases on the latest aging research, plus interviews and from the distinguished network of authors who continue to publish their research with Aging-US.

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Aging-US Authors

Figure 1. Identification of CaV blockers as a potential new class of senolytics.
Aging News

Benidipine Calcium Channel Blocker Improves Cigarette Smoke-Induced Lung Emphysema

December 20, 2023December 21, 2023

PRESS RELEASE: A new research paper was published in Aging’s Volume 15, Issue 23, entitled, “Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema.”

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Figure 2. Comprehensive transcriptional analysis of senescent corneal and conjunctival epithelial cells.
Aging News

Genetic Profiles of Senescent Corneal and Conjunctival Epithelial Cells in Humans

October 2, 2023October 2, 2023

PRESS RELEASE: A new priority research paper was published on the cover of Aging’s Volume 15, Issue 18, entitled, “Gene expression signatures of human senescent corneal and conjunctival epithelial cells.”

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Figure 1. Experimental design. To investigate senescence in osteoarthritic chondrocytes, primary human articular chondrocytes (HACs) were stimulated with etoposide for 24 h (blue) or with IL-1β for 8 days (red) with treatment renewal at days 3 and 6. Senescence features were assessed at days 1 and 8 in both conditions by qPCR, WB, and immunofluorescence.
Aging News

DNA Damage-induced Senescence Model in Osteoarthritic Chondrocytes

September 20, 2023September 20, 2023

A new research paper was published in Aging’s Volume 15, Issue 17, entitled, “Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes.”

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Figure 4. The secretome of senescent human lung fibroblasts as mediator of murine lung fibrosis.
Aging News

Human Senescent Fibroblasts Cause Lung Fibrosis in Mice

July 31, 2023July 31, 2023

PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 14, entitled, “Human senescent fibroblasts trigger progressive lung fibrosis in mice.”

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Figure 2. Cholangiocytes and perinodular hepatocytes display cellular senescence in BA livers.
Aging News

Senescence and Senotherapies in Biliary Atresia and Biliary Cirrhosis

June 28, 2023June 28, 2023

PRESS RELEASE: A new research paper was published in Aging’s Volume 15, Issue 11, entitled, “Senescence and senotherapies in biliary atresia and biliary cirrhosis.”

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Figure 1. Cell culture supernatant, containing NF-κB-dependent pro-inflammatory senescence-associated secretory phenotype (SASP), was collected from senescent normal human fibroblasts and used to treat human epithelial breast cancer cells.
Aging News

The Senescence-Associated Secretory Phenotype Induces Neuroendocrine Transdifferentiation

May 12, 2023May 12, 2023

PRESS RELEASE: A new editorial paper was published in Aging’s Volume 15, Issue 8, entitled, “The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation.”

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Figure 1. Proposed mechanism showing the parallels between age-associated brain and vascular amyloidosis, with both being mediated by sEVs and affected by cellular senescence.
Aging News

Senescence and Extracellular Vesicles: Novel Partners in Vascular Amyloidosis

March 29, 2023March 30, 2023

PRESS RELEASE: A new editorial paper was published in Aging’s Volume 15, Issue 5, entitled, “Senescence and extracellular vesicles: novel partners in vascular amyloidosis.”

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Figure 1 (Fragmented): t-SNE visualization of 14,588 old and young peripheral blood cells.
Aging News

Aging | Single-Cell Transcriptomics of Peripheral Blood in Aging Mouse

January 17, 2023January 17, 2023

PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 1, entitled, “Single-cell transcriptomics of peripheral blood in the aging mouse.”

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Aging
Aging News

Aging | Synergism of BCL-2 Family Inhibitors Facilitates Selective Elimination of Senescent Cells

September 1, 2022September 6, 2022

PRESS RELEASE: A new research paper was published in Aging’s Volume 14, Issue 16, entitled, “Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells.”

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Aging
Aging News

Aging-US | DDIT4 Identified as Candidate Target of HDAC4-Associated Skin Aging

June 15, 2022June 16, 2022

PRESS RELEASE: In Aging’s latest cover paper, researchers conducted a new study to elucidate the potential role of HDAC4 in the regulation of cellular senescence and skin aging.

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