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Aging-US.net features press releases on the latest aging research, plus interviews and from the distinguished network of authors who continue to publish their research with Aging-US.

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Aging-US Authors

Figure 1. Morphological changes of human corneal endothelial cells after UV-A exposition.
Aging News

Cover Paper: Senescent Characteristics of Human Corneal Endothelial Cells Upon UV-A Exposure

April 30, 2024April 30, 2024

PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 16, Issue 8, entitled, “Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure.”

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Figure 8. PR55α level is much lower in human normal tissue specimens of older individuals compared to younger individuals and inversely correlates with p16 levels. Human normal tissue specimens derived from various organs/sites were analyzed for differences in PR55α and p16 expression by IHC.
Aging News

PR55α-controlled PP2A Inhibits p16 Expression and Blocks Cellular Senescence Induction

March 19, 2024

PRESS RELEASE: On March 4, 2024, a new research paper was published in Aging’s Volume 16, Issue 5, entitled, “PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation.”

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Figure 6. Immunotherapy response prediction of senescence related TME risk model and STCGs expression in single cell level.
Aging News

Prognostic Significance of Senescence-related TME Genes in Head and Neck Squamous Cell Carcinoma

January 31, 2024January 31, 2024

PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 16, Issue 2, entitled, “Prognostic significance of senescence-related tumor microenvironment genes in head and neck squamous cell carcinoma.”

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Figure 1. Identification of CaV blockers as a potential new class of senolytics.
Aging News

Benidipine Calcium Channel Blocker Improves Cigarette Smoke-Induced Lung Emphysema

December 20, 2023December 21, 2023

PRESS RELEASE: A new research paper was published in Aging’s Volume 15, Issue 23, entitled, “Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema.”

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Figure 2. Comprehensive transcriptional analysis of senescent corneal and conjunctival epithelial cells.
Aging News

Genetic Profiles of Senescent Corneal and Conjunctival Epithelial Cells in Humans

October 2, 2023October 2, 2023

PRESS RELEASE: A new priority research paper was published on the cover of Aging’s Volume 15, Issue 18, entitled, “Gene expression signatures of human senescent corneal and conjunctival epithelial cells.”

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Figure 1. Experimental design. To investigate senescence in osteoarthritic chondrocytes, primary human articular chondrocytes (HACs) were stimulated with etoposide for 24 h (blue) or with IL-1β for 8 days (red) with treatment renewal at days 3 and 6. Senescence features were assessed at days 1 and 8 in both conditions by qPCR, WB, and immunofluorescence.
Aging News

DNA Damage-induced Senescence Model in Osteoarthritic Chondrocytes

September 20, 2023September 20, 2023

A new research paper was published in Aging’s Volume 15, Issue 17, entitled, “Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes.”

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Figure 4. The secretome of senescent human lung fibroblasts as mediator of murine lung fibrosis.
Aging News

Human Senescent Fibroblasts Cause Lung Fibrosis in Mice

July 31, 2023July 31, 2023

PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 14, entitled, “Human senescent fibroblasts trigger progressive lung fibrosis in mice.”

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Figure 2. Cholangiocytes and perinodular hepatocytes display cellular senescence in BA livers.
Aging News

Senescence and Senotherapies in Biliary Atresia and Biliary Cirrhosis

June 28, 2023June 28, 2023

PRESS RELEASE: A new research paper was published in Aging’s Volume 15, Issue 11, entitled, “Senescence and senotherapies in biliary atresia and biliary cirrhosis.”

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Figure 1. Cell culture supernatant, containing NF-κB-dependent pro-inflammatory senescence-associated secretory phenotype (SASP), was collected from senescent normal human fibroblasts and used to treat human epithelial breast cancer cells.
Aging News

The Senescence-Associated Secretory Phenotype Induces Neuroendocrine Transdifferentiation

May 12, 2023May 12, 2023

PRESS RELEASE: A new editorial paper was published in Aging’s Volume 15, Issue 8, entitled, “The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation.”

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Figure 1. Proposed mechanism showing the parallels between age-associated brain and vascular amyloidosis, with both being mediated by sEVs and affected by cellular senescence.
Aging News

Senescence and Extracellular Vesicles: Novel Partners in Vascular Amyloidosis

March 29, 2023March 30, 2023

PRESS RELEASE: A new editorial paper was published in Aging’s Volume 15, Issue 5, entitled, “Senescence and extracellular vesicles: novel partners in vascular amyloidosis.”

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