With aging, bone mass declines and the anabolic effects of skeletal loading diminish. While much research has focused on gene transcription, how bone ages and loses its mechanoresponsiveness at the protein level remains unclear. We developed a novel proteomics approach and performed a paired mass spectrometry and RNA-seq analysis on tibias from young-adult (5-month) and old (22-month) mice.
Aging (Aging-US) Authors
A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science), Volume 16, Issue 19 on October 12, 2024, entitled, “A proteomics approach to study mouse long bones: examining baseline differences and mechanical loading-induced bone formation in young-adult and old mice.”
Dean Bunnell, PhD candidate from the University of Alabama, describes a research paper he co-authored that was published by Aging (Aging-US), entitled, “RNA virus-mediated changes in organismal oxygen consumption rate in young and old Drosophila melanogaster males.”
PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 1, entitled, “Single-cell transcriptomics of peripheral blood in the aging mouse.”
PRESS RELEASE: A new review paper was published in Aging’s Volume 14, Issue 19, entitled, “RNA modifications in aging-associated cardiovascular diseases.”