In Alzheimer’s disease (AD), platelets become dysfunctional and might contribute to amyloid beta deposition. Here, the researchers depleted platelets in one-year-old APP Swedish PS1 dE9 (APP-PS1) transgenic mice for five days, using intraperitoneal injections of an anti-CD42b antibody, and assessed changes in cerebral amyloidosis, plaque-associated neuritic dystrophy and gliosis…
Aging (Aging-US) Authors
PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 3, entitled, “Immune-mediated platelet depletion augments Alzheimer’s disease neuropathological hallmarks in APP-PS1 mice.”
PRESS RELEASE: A new research paper was published in Aging’s Volume 15, Issue 2, entitled, “Body weight influences musculoskeletal adaptation to long-term voluntary wheel running during aging in female mice.”
PRESS RELEASE: Dr. Blagosklonny published a new research perspective in Aging’s Volume 15, Issue 2, entitled, “Are menopause, aging and prostate cancer diseases?”
Type 2 diabetes is partly characterized by decreased β-cell mass and function which have been linked to cellular senescence. Despite a low basal proliferative rate of adult β-cells, they can respond to growth stimuli, but this proliferative capacity decreases with age and correlates with increased expression of senescence effector, p16Ink4a.
PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 2, entitled, “Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change β-cell mass and has limited effects on their proliferative capacity.”