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Figure 6. Mechanisms proposed in this study. Cellular senescence
Aging News

Cellular Senescence Involves Gene Repression Through p53-p16/RB-E2F-DREAM Complex

June 13, 2023June 13, 2023

PRESS RELEASE: A new research paper was published in Aging’s Volume 15, Issue 10, entitled, “Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex.”

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Figure 1. Zoledronic acid has senolytic effects in human lung fibroblast IMR90 cells.
Aging News

Effects of Zoledronic Acid on Senescence and SASP Markers

May 15, 2023May 15, 2023

PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 9, entitled, “In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers.”

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Figure 1. Cell culture supernatant, containing NF-κB-dependent pro-inflammatory senescence-associated secretory phenotype (SASP), was collected from senescent normal human fibroblasts and used to treat human epithelial breast cancer cells.
Aging News

The Senescence-Associated Secretory Phenotype Induces Neuroendocrine Transdifferentiation

May 12, 2023May 12, 2023

PRESS RELEASE: A new editorial paper was published in Aging’s Volume 15, Issue 8, entitled, “The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation.”

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Figure 3. Cell states evolving over time after ETO-induced senescence.
Aging News

Single-Cell Transcriptomic Analysis Uncovers Diverse and Dynamic Senescent Cell Populations

May 9, 2023May 9, 2023

PRESS RELEASE: A new research paper was published in Aging’s Volume 15, Issue 8, entitled, “Single-cell transcriptomic analysis uncovers diverse and dynamic senescent cell populations.”

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Figure 1. Oxidative stress-induced wounding results in a chronic wound with increased SA-β-gal expression and SASP burden.
Aging News

A Chronic Wound Model to Investigate Skin Cellular Senescence

May 1, 2023May 1, 2023

PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 8, entitled, “A chronic wound model to investigate skin cellular senescence.”

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Figure 4. Mechanisms of cell death induced by CUDC-907 in senescent cells.
Aging News

Characterization of the HDAC/PI3K Inhibitor CUDC-907 as a Novel Senolytic

April 25, 2023April 26, 2023

PRESS RELEASE: A new research paper was published in Aging’s Volume 15, Issue 7, entitled, “Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic.”

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Figure 5. Epithelial and endothelial cell populations mediate p21-dependent inflammatory responses following chronic LPS inhalation.
Aging News

p21 Facilitates Chronic Lung Inflammation via Epithelial and Endothelial Cells

April 17, 2023April 18, 2023

PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 7, entitled, “p21 facilitates chronic lung inflammation via epithelial and endothelial cells.”

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Figure 7. Summary schematic of MET+LEU effects during SD in muscle cells.
Aging News

Metformin & Leucine Prevent Cellular Senescence & Proteostasis Disruption

March 31, 2023March 31, 2023

PRESS RELEASE: A new research paper was published on the cover of Aging’s Volume 15, Issue 6, entitled, “Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail.”

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Figure 6. Senescence / Senescent EXO exchange promotes activated MSC phenotype.
Aging News

Aging | Senescence-Associated Exosomes Transfer Fibrosis to Neighboring Cells

March 17, 2023March 17, 2023

PRESS RELEASE: A new research paper was published in Aging’s Volume 15, Issue 5, entitled, “Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells.”

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Figure 1. Geroconversion as a form of growth.
Aging News

Aging | Cellular Senescence: When Growth Stimulation Meets Cell Cycle Arrest

March 2, 2023March 2, 2023

PRESS RELEASE: Aging published a new review paper in Volume 15, Issue 4, entitled, “Cellular senescence: when growth stimulation meets cell cycle arrest.”

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